Introduction:
Proteomics is important to study due to the accurate reflection of what is occurring in the system. Studying all proteins at one time in a specific environment reveals how the system is functioning at that point in time. Protein interactions are important to study due to possible revelations of pathways and their molecular functioning [1]. The STRING database can be used to easily access previously studied protein interactions associated with a protein of interest [2]. This resource has the potential to reveal possible interactions associated with increased serum ferritin and perforin loss.
Proteomics is important to study due to the accurate reflection of what is occurring in the system. Studying all proteins at one time in a specific environment reveals how the system is functioning at that point in time. Protein interactions are important to study due to possible revelations of pathways and their molecular functioning [1]. The STRING database can be used to easily access previously studied protein interactions associated with a protein of interest [2]. This resource has the potential to reveal possible interactions associated with increased serum ferritin and perforin loss.
Discussion:
PRF1 has similar protein networks in both Homo Sapiens and Danio Rerio, with both being heavily involved in T- cell proliferation pathways (green) as well as the innate immune response (blue) [2].
PRF1 has similar protein networks in both Homo Sapiens and Danio Rerio, with both being heavily involved in T- cell proliferation pathways (green) as well as the innate immune response (blue) [2].
References:
[1] Al-Amrani, Safa, et al. “Proteomics: Concepts and Applications in Human Medicine.” World Journal of Biological Chemistry, U.S. National Library of Medicine, 27 Sept. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8473418/#:~:text=Proteomics%20is%20the%20study%20of,of%20the%20organism%20than%20genomics.
[2] Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Annika GL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C. The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023 Jan 6;51(D1):D638-646
[1] Al-Amrani, Safa, et al. “Proteomics: Concepts and Applications in Human Medicine.” World Journal of Biological Chemistry, U.S. National Library of Medicine, 27 Sept. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8473418/#:~:text=Proteomics%20is%20the%20study%20of,of%20the%20organism%20than%20genomics.
[2] Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Annika GL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C. The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023 Jan 6;51(D1):D638-646